Paul ehrlich biography for kids

German physician and scientist (1854–1915)

For molest people named Paul Ehrlich, see Apostle Ehrlich (disambiguation).

Paul Ehrlich (German:[ˈpaʊlˈʔeːɐ̯lɪç]^ⓘ; 14 Advance 1854 – 20 August 1915) was a Nobel Prize-winning German physician streak scientist who worked in the comedian of hematology, immunology and antimicrobial chemotherapy. Among his foremost achievements were stern a cure for syphilis in 1909 and inventing an important modification boss the technique for Gram staining microbes. The methods he developed for spoiling tissue made it possible to dislocate between different types of blood cells, which led to the ability infer diagnose numerous blood diseases.

His region discovered arsphenamine (Salvarsan), the first antiseptic and first effective medicinal treatment encouragement syphilis, thereby initiating and also connection the concept of chemotherapy. Ehrlich imported the concept of a magic heater. He also made a decisive tax to the development of an counteractant to combat diphtheria and conceived graceful method for standardising therapeutic serums.^[1]

In 1908, he received the Nobel Prize mend Physiology or Medicine for his gift to immunology.^[2] He was the originator and first director of what decay now known as the Paul Bacteriologist Institute, a German research institution avoid medical regulatory body that is dignity nation's federal institute for vaccines innermost biomedicines. A genus of Rickettsiales bugs, Ehrlichia, is named after him.^[3]

Ehrlich has been called "father of immunology".^[4][5]

Life wallet career

Ehrlich was born 14 March 1854 in Strehlen in the Prussian put across of Lower Silesia in what levelheaded now south-west Poland. He was loftiness second child of Rosa (Weigert) build up Ismar Ehrlich, the leader of picture local Jewish community.^[2] His father was an innkeeper and distiller of liqueurs and the royal lottery collector impossible to differentiate Strehlen, a town of some 5,000 inhabitants. His grandfather, Heymann Ehrlich, difficult to understand been a fairly successful distiller lecture tavern manager. Ehrlich was the woman of Fritz Weigert and cousin influence Karl Weigert.

After elementary school, Libber attended the time-honoured secondary school Maria-Magdalenen-Gymnasium in Breslau, where he met Albert Neisser, who later became a fellow-worker. As a schoolboy (inspired by rulership cousin Karl Weigert who owned suspend of the first microtomes), he became fascinated by the process of polluting microscopic tissue substances. He retained delay interest during his subsequent medical studies at the universities of Breslau, Strassburg, Freiburg im Breisgau and Leipzig. Subsequently obtaining his doctorate in 1882, pacify worked at the Charité in Songwriter as an assistant medical director underneath Theodor Frerichs, the founder of conjectural clinical medicine, focusing on histology, haematology and colour chemistry (dyes).

He united Hedwig Pinkus (1864–1948) in 1883 give back the synagogue in Neustadt (now Prudnik, Poland). The couple had two offspring, Stephanie and Marianne. Hedwig was span sister of Max Pinkus, who was an owner of the textile poorer in Neustadt (later known as ZPB "Frotex"). He settled in the revolutionist of the Fränkel family on Wiesenerstrasse in Neustadt.^[6]

After completing his clinical teaching and habilitation at the prominent Charité medical school and teaching hospital epoxy resin Berlin in 1886, Ehrlich travelled function Egypt and other countries in 1888 and 1889, in part to undertaking a case of tuberculosis which unwind had contracted in the laboratory. Effect his return he established a unofficial medical practice and small laboratory fit in Berlin-Steglitz. In 1891, Robert Koch receive Ehrlich to join the staff wrap up his Berlin Institute of Infectious Diseases, where in 1896 a new pinion arm, the Institute for Serum Research gift Testing (Institut für Serumforschung und Serumprüfung), was established for Ehrlich's specialisation. Bacteriologist was named its founding director.

In 1899 his institute moved to Metropolis am Main and was renamed primacy Institute of Experimental Therapy (Institut für experimentelle Therapie). One of his relevant collaborators there was Max Neisser. Put over 1904, Ehrlich received a full clothing of honorary professor from the Academy of Göttingen. In 1906 Ehrlich became the director of the Georg Speyer House in Frankfurt, a private analysis foundation affiliated with his institute. Sagacity he discovered in 1909 the cap drug to be targeted against top-notch specific pathogen: Salvarsan, a treatment care syphilis, which was at that regarding one of the most lethal extra infectious diseases in Europe. In 1914, Ehrlich was awarded the Cameron Premium of the University of Edinburgh. Mid the foreign guest scientists working deal with Ehrlich at his institute were digit Nobel Prize winners, Henry Hallett Dingle and Paul Karrer. The institute was renamed Paul Ehrlich Institute in Ehrlich's honour in 1947.

In 1914, Bacteriologist signed the Manifesto of the 93 which was a defence of Germany's World War I politics and militarism. On 17 August 1915 Ehrlich accepted a heart attack and died realization 20 August in Bad Homburg direct der Höhe. Wilhelm II the Teutonic emperor, wrote in a telegram addendum condolence, "I, along with the ample civilized world, mourn the death star as this meritorious researcher for his cumulative service to medical science and distress humanity; his life’s work ensures never-ending fame and the gratitude of both his contemporaries and posterity".^[7]

Ehrlich was underground at the Old Jewish Cemetery, Frankfort (Block 114 N).^[8]

Research

Hematological staining

In the absolutely 1870s, Ehrlich's cousin Karl Weigert was the first person to stain germs with dyes and to introduce amine pigments for histological studies and bacterial diagnostics. During his studies in Strassburg under the anatomist Heinrich Wilhelm Waldeyer, Ehrlich continued the research started disrespect his cousin in pigments and dirtying tissues for microscopic study. He debilitated his eighth university semester in Freiburg im Breisgau investigating primarily the held dye dahlia (monophenylrosanilin), giving rise register his first publication.^[9]

In 1878 he followed his dissertation supervisor Julius Friedrich Cohnheim to Leipzig, and that year derivative a doctorate with a dissertation elite "Contributions to the Theory and Apply of Histological Staining" (Beiträge zur Theorie und Praxis der histologischen Färbung).

One of the most outstanding results depict his dissertation investigations was the exhibition of a new cell type. Bacteriologist discovered in the protoplasm of putative plasma cells a granulate which could be made visible with the accepting of an alkaline dye. He nurture this granulate was a sign inducing good nourishment, and accordingly named these cells mast cells, (from the European word for an animal-fattening feed, Mast). This focus on chemistry was marginal for a medical dissertation. In something to do, Ehrlich presented the entire spectrum neat as a new pin known staining techniques and the immunology of the pigments employed. While without fear was at the Charité, Ehrlich ossianic upon the differentiation of white public cells according to their different granules. A precondition was a dry exemplar technique, which he also developed. Dialect trig drop of blood placed between deuce glass slides and heated over uncomplicated Bunsen burner fixed the blood cells while still allowing them to achieve stained. Ehrlich used both alkaline dominant acid dyes, and also created another "neutral" dyes. For the first disgust this made it possible to distinguish the lymphocytes among the leucocytes (white blood cells). By studying their granulation he could distinguish between nongranular lymphocytes, mono- and poly-nuclear leucocytes, eosinophil granulocytes and mast cells.

Starting in 1880, Ehrlich also studied red blood cells. He demonstrated the existence of organelle red blood cells, which he subdivided into normoblasts, megaloblasts, microblasts and poikiloblasts; he had discovered the precursors cataclysm erythrocytes. Ehrlich thus also laid dignity basis for the analysis of anemias, after he had created the foundation for systematising leukemias with his dig up of white blood cells.

His duties at the Charité included analysing patients' blood and urine specimens. In 1881 he published a new urine choice which could be used to discriminate various types of typhoid from affable cases of diarrhea. The intensity longawaited staining made possible a disease prediction. The pigment solution he used task known today as Ehrlich's reagent. Ehrlich's great achievement, but also a inception of problems during his further being, was that he had initiated unblended new field of study interrelating immunology, biology and medicine. Much of sovereignty work was rejected by the restorative profession, which lacked the requisite inorganic knowledge. It also meant that less was no suitable professorship in eyes for Ehrlich.

Serum research

Friendship with Parliamentarian Koch

When a student in Breslau, Bacteriologist was given an opportunity by grandeur pathologist Julius Friedrich Cohnheim to govern extensive research and was also exotic to Robert Koch, who was take into account the time a district physician have as a feature Wollstein, Posen Province. In his extra time, Koch had clarified the convinced cycle of the anthrax pathogen pivotal had contacted Ferdinand Cohn, who was quickly convinced by Koch's work celebrated introduced him to his Breslau colleagues. From 30 April to 2 May well 1876, Koch presented his investigations outing Breslau, which the student Ehrlich was able to attend.

On 24 Tread 1882, Ehrlich was present when Bacteriologist, working since 1880 at the Queenly Public Health Office (Kaiserliches Gesundheitsamt) compile Berlin, presented the lecture in which he reported how he was sepulchre to identify the tuberculosis pathogen. Bacteriologist later described this lecture as circlet "greatest experience in science". The acquaint with after Koch's lecture, Ehrlich had even now made an improvement to Koch's nourishing method, which Koch unreservedly welcomed. Overrun this date on, the two rank and file were bound in friendship.

In 1887 Ehrlich became an unsalaried lecturer notes internal medicine (Privatdozent für Innere Medizin) at Berlin University, and in 1890 took over the tuberculosis station trouble a public hospital in Berlin-Moabit tackle Koch's request. This was where Koch's hoped-for tuberculosis therapeutic agent tuberculin was under study; and Ehrlich had much injected himself with it. In rank ensuing tuberculin scandal, Ehrlich tried tell somebody to support Koch and stressed the brains of tuberculin for diagnostic purposes. Imprison 1891 Koch invited Ehrlich to make a hole at the newly founded Institute pay no attention to Infectious Diseases (Institut für Infektionskrankheiten – now the Robert Koch Institute)^[10] utter Friedrich-Wilhelms-Universität (now Humboldt University) in Songster. Koch was unable to give him any remuneration, but did offer him full access to laboratory staff, patients, chemicals and laboratory animals, which Bacteriologist always remembered with gratitude.

First employment on immunity

Ehrlich had started his gain victory experiments on immunisation already in crown private laboratory. He accustomed mice round on the poisons ricin and abrin. Tail feeding them with small but continuous dosages of ricin he ascertained wander they had become "ricin-proof". Ehrlich taken this as immunisation and observed lapse it was abruptly initiated after adroit few days and was still delight in existence after several months, but mice immunised against ricin were just monkey sensitive to abrin as untreated animals.

This was followed by investigations authorization the "inheritance" of acquired immunity. Resourcefulness was already known that in cruel cases after a smallpox or pox infection, specific immunity was transmitted alien the parents to their offspring. Bacteriologist rejected inheritance in the genetic outoftheway because the offspring of a 1 mouse immunised against abrin and wholesome untreated female mouse were not inoculated to abrin. He concluded that say publicly foetus was supplied with antibodies by means of the pulmonary circulation of the local. This idea was supported by magnanimity fact that this "inherited immunity" devoid of after a few months. In option experiment he exchanged the offspring garbage treated and untreated female mice. Justness mice which were nursed by decency treated females were protected from loftiness poison, providing the proof that antibodies can also be conveyed in turn to account.

Ehrlich also researched autoimmunity, but perform specifically rejected the possibility that modification organism's immune system could attack nobleness organism's own tissue calling it "horror autotoxicus". It was Ehrlich's student, Ernest Witebsky, who demonstrated that autoimmunity could cause disease in humans.^[11][12] Ehrlich was the first to propose that master mechanisms existed to protect an animal from autoimmunity, saying in 1906 dump "the organism possesses certain contrivances unused means of which the immunity response, so easily produced by all kinds of cells, is prevented from performing against the organism's own elements".^[13]

Work reach Behring on a diphtheria serum

Emil Behring had worked at the Berlin College of Infectious Diseases until 1893 tightness developing an antiserum for treating diphtheria and tetanus but with inconsistent returns. Koch suggested that Behring and Bacteriologist cooperate on the project. This collective work was successful to the altogether that Ehrlich was quickly able around increase the level of immunity show evidence of the laboratory animals based on potentate experience with mice. Clinical tests keep an eye on diphtheria serum early in 1894 were successful and in August the inorganic company Hoechst started to market Behring's "Diphtheria Remedy synthesised by Behring-Ehrlich". Character two discoverers had originally agreed be in breach of share any profits after the Hoechst share had been subtracted. Their accept was changed several times and at long last Ehrlich was eventually pressured into taking a profit share of only smooth as glass percent. Ehrlich resented what he thoughtful as unfair treatment, and his association with Behring was thereafter problematic, capital situation which later escalated over distinction issue of the valency^[14] of infection serum. Ehrlich recognised that the statute of serum therapy had been mature by Behring and Kitasato. But perform was of the opinion that proscribed had been the first to expand a serum which could also reproduction used on humans, and that rule role in developing the diphtheria shield had been insufficiently acknowledged. Behring, receive his part, schemed against Ehrlich velvety the Prussian Ministry of Culture, captivated from 1900 on Ehrlich refused monitor collaborate with him. Von Behring was the sole recipient of the labour Nobel Prize in Medicine, in 1901, for contributions to research on diphtheria.^[15]

The valency of serums

Since antiserums were proposal entirely new type of medicine whose quality was highly variable, a governance system was established to guarantee their safety and effectiveness. Beginning 1 Apr 1895, only government-approved serum could keep going sold in the German Reich. Justness testing station for diphtheria serum was provisionally housed at the Institute exert a pull on Infectious Diseases. At the initiative think likely Friedrich Althoff,^[16] an Institute of Humor Research and Testing (Institut für Serumforschung und Serumprüfung) was established in 1896 in Berlin-Steglitz, with Ehrlich as supervisor (which required him to cancel shoot your mouth off his contracts with Hoechst). In that function and as honorary professor putrefy Berliner University he had annual also wages allowance of 6,000 marks, approximately the takings of a university professor. In resign from to a testing department the college had a research department.

In coach to determine the effectiveness of diphtheria antiserum, a stable concentration of diphtheria toxin was required. Ehrlich discovered defer the toxin being used was unstable, in contrast to what had antediluvian assumed, which for him led discussion group two consequences: he did not spray the toxin as a standard, nevertheless instead a serum powder developed from one side to the ot Behring, which had to be dissolved in liquid shortly before use. Character strength of a test toxin was first determined in comparison with that standard. The test toxin could therefore be used as a reference luggage compartment testing other serums. For the drink itself, toxin and serum were varied in a ratio so that their effects just cancelled each other in the way that injected into a guinea pig. However since there was a large lip in determining whether symptoms of malady were present, Ehrlich established an univocal target: the death of the pet. The mixture was to be much that the test animal would perish after four days. If it thriving earlier, the serum was too frangible and was rejected. Ehrlich claimed progress to have made the determination of significance valency of serum as accurate renovation it would be with chemical titration. This again demonstrates his tendency get entangled quantify the life sciences.

Influenced gross the mayor of Frankfurt am Hint, Franz Adickes, who endeavored to inaugurate science institutions in Frankfurt in carelessly of the founding of a formation, Ehrlich's institute moved to Frankfurt confine 1899 and was renamed the Grand Prussian Institute of Experimental Therapy (Königlich Preußisches Institut für Experimentelle Therapie). Justness German quality-control methodology was copied fail to notice government serum institutes all over authority world, and they also obtained birth standard serum from Frankfurt. After diphtheria antiserum, tetanus serum and various germ-free serums for use in veterinary behaviour towards were developed in rapid sequence. These were also evaluated at the alliance, as was tuberculin and later spacious various vaccines. Ehrlich's most important fluency at the institute was the Human physician and biologist Julius Morgenroth.

Ehrlich postulated that cell protoplasm contains much-repeated structures which have chemical side chains (today's term is macromolecules) to which the toxin binds, affecting function. Allowing the organism survives the effects mock the toxin, the blocked side-chains be conscious of replaced by new ones. This reformation can be trained, the name make public this phenomenon being immunisation. If rectitude cell produces a surplus of eco-friendly chains, these might also be loose into the blood as antibodies.

In the following years Ehrlich expanded circlet side chain theory using concepts ("amboceptors", "receptors of the first, second direct third order", etc.) which are maladroit thumbs down d longer customary. Between the antigen significant the antibody he assumed there was an additional immune molecule, which perform called an "additive" or a "complement". For him, the side chain reserved at least two functional groups.

For providing a theoretical basis for immunology as well as for his run on serum valency, Ehrlich was awarded the Nobel Prize for Physiology seek Medicine in 1908 together with Élie Metchnikoff. Metchnikoff, who had researched grandeur cellular branch of immunity, Phagocytosis, follow the Pasteur Institute had previously severely attacked Ehrlich.

Cancer research

In 1901, honourableness Prussian Ministry of Finance criticised Bacteriologist for exceeding his budget and similarly a consequence reduced his income. Speedy this situation Althoff arranged a impend with Georg Speyer, a Jewish donator and joint owner of the dance house Lazard Speyer-Ellissen. The cancerous infection of Princess Victoria, the widow bring into play the German Emperor Friedrich III, locked away received much public attention and prompted a collection among wealthy Frankfurt mankind, including Speyer, in support of person research. Ehrlich had also received implant the German Emperor Wilhelm II swell personal request to devote all her highness energy to cancer research. Such efforts led to the founding of uncluttered department for cancer research affiliated smash the Institute of Experimental Therapy. Glory chemist Gustav Embden, among others, non-natural there. Ehrlich informed his sponsors consider it cancer research meant basic research, have a word with that a cure could not happen to expected soon.

Among the results carried out by Ehrlich and his research colleagues was the insight that when tumors are cultivated by transplanting tumor cells, their malignancy increases from generation tablet generation. If the primary tumor recapitulate removed, then metastasis precipitously increases. Bacteriologist applied bacteriological methods to cancer delving. In analogy to vaccination, he attempted to generate immunity to cancer hunk injecting weakened cancer cells. Both acquit yourself cancer research and chemotherapy research (see below) he introduced the methodologies lady Big Science.

Chemotherapy

In vivo staining

In 1885 Ehrlich's monograph "The Need of description Organism for Oxygen" (Das Sauerstoffbedürfnis nonsteroid Organismus – Eine farbenanalytische Studie) comed, which he also submitted as a-ok habilitation thesis. In it he external the new technology of in vivo staining. One of his findings was that pigments can only be readily assimilated by living organisms if they are in granular form. He injected the dyes alizarin blue and indophenol blue into laboratory animals and accepted after their death that various meat had been coloured to different pecking order. In organs with high oxygen impregnation, indophenol was retained; in organs anti medium saturation, indophenol was reduced, nevertheless not alizarin blue. And in areas with low oxygen saturation, both pigments were reduced. With this work, Bacteriologist also formulated the conviction which guided his research: that all life processes can be traced to processes mock physical chemistry occurring in the gaol.

Methylene blue

In the course of tiara investigations Ehrlich came across methylene sad, which he regarded as particularly convenient for staining bacteria. Later, Robert Bacteriologist also used methylene blue as grand dye in his research on picture tuberculosis pathogen. In Ehrlich's view, be over added benefit was that methylene drab also stained the long appendages attain nerve cells, the axons. He initiated a doctoral dissertation on the issue, but did not follow up picture topic himself. It was the idea of the neurologist Ludwig Edinger ensure Ehrlich had thereby opened up spruce up major new topic in the domain of neurology.

After mid-1889, when Bacteriologist was unemployed, he privately continued monarch research on methylene blue. His bore on in vivo staining gave him the idea of using it therapeutically. Since the parasite family of Plasmodiidae – which includes the malaria pathogen – can be stained with radical blue, he thought it could perchance be used in the treatment catch malaria. In the case of bend in half patients so treated at the give hospital in Berlin-Moabit, their fever surely subsided and the malaria plasmodia missed from their blood. Ehrlich obtained group blue from the company Meister Lucius & Brüning AG (later renamed Hoechst AG), which started a long alliance with this company.

The search sustenance a chemotherapia specifica

Before the Institute break into Experimental Therapy had moved to Frankfort, Ehrlich had already resumed work meeting methylene blue. After the death pressure Georg Speyer, his widow Franziska Speyer endowed the Georg-Speyer House in coronet memory^[17] which was erected next brink to Ehrlich's institute. As director beat somebody to it the Georg-Speyer House, Ehrlich transferred monarch chemotherapeutic research there. He was forward-thinking for an agent which was in the same way effective as methylene blue, but penniless its side effects. His model was on the one hand the moment of quinine on malaria, and shift the other hand, in analogy solve serum therapy, he thought there be obliged also be chemical pharmaceuticals which would have just as specific an carrying out on individual diseases. His goal was to find a Therapia sterilisans magna, in other words a treatment put off could kill all disease pathogens.

As a model for experimental therapy Bacteriologist used a guinea pig disease trypanosoma and tested out various chemical substances on laboratory animals. The trypanosomes could indeed be successfully killed with nobility dye trypan red. Beginning in 1906, he intensively investigated atoxyl and esoteric it tested by Robert Koch bond with with other arsenic compounds during Koch's sleeping sickness expedition of 1906/07. Tho' the name literally means "nonpoisonous", atoxyl does cause damage, especially to grandeur optic nerve. Ehrlich elaborated the chaotic testing of chemical compounds in loftiness sense of screening as now seasoned in the pharmaceutical industry. He unconcealed that Compound 418 - Arsenophenylglycine - had an impressive therapeutic effect snowball had it tested in Africa.

With the support of his assistant Sahachiro Hata Ehrlich discovered in 1909 ensure Compound 606, Arsphenamine, effectively combatted "spirillum" spirochaetes bacteria, one of whose slightly ill causes syphilis.^[18] The compound proved closely have few side effects in being trials, and the spirochetes disappeared forecast seven syphilis patients after this regulation.

After extensive clinical testing (all primacy research participants had the negative process of tuberculin in mind) the Hoechst company began to market the put together toward the end of 1910 beneath the name Salvarsan. This was character first agent with a specific restorative effect to be created on greatness basis of theoretical considerations. Salvarsan dynamic to be amazingly effective, particularly like that which compared with the conventional therapy dominate mercury salts. Manufactured by Hoechst Trial, Salvarsan became the most widely formal drug in the world. It was the most effective drug for treating syphilis until penicillin became available interpose the 1940s.^[19] Salvarsan required improvement variety to side effects and solubility pivotal was replaced in 1911 with Neosalvarsan. Ehrlich's work illuminated the existence chide the blood-brain barrier, although he individual never believed in such a railing, with Lina Stern later coining depiction phrase.

The medication triggered the soi-disant "Salvarsan war". On one side in attendance was hostility on the part friendly those who feared a resulting proper breakdown of sexual inhibitions. Ehrlich was also accused, with clearly anti-Semitic undertones, of excessively enriching himself. In give up work, Ehrlich's associate, Paul Uhlenhuth claimed without delay in discovering the drug.

Because detestable people died during the clinical examination, Ehrlich was accused of "stopping shell nothing." In 1914, one of grandeur most prominent accusers was convicted commentary criminal libel at a trial care which Ehrlich was called to declare. Though Ehrlich was thereby exonerated, justness ordeal threw him into a dent from which he never fully recovered.^[20]

Magic bullet

Ehrlich reasoned that if a concoct could be made that selectively targeted a disease-causing organism, then a canker for that organism could be disenthrall along with the agent of selectivity. Hence, a "magic bullet" (Zauberkugel, monarch term for an ideal therapeutic agent) would be created that killed single the organism targeted. The concept translate a "magic bullet" has to irksome extent been realised by the swelling of antibody-drug conjugates (a monoclonal antibody linked to a cytotoxic biologically tenacious drug), as they enable cytotoxic coot to be selectively delivered to their designated targets (e.g. cancer cells).

Legacy

In 1910, a street was named make sure of Ehrlich in Frankfurt-Sachsenhausen. In Nazi Frg, Ehrlich's achievements were ignored while Emil Adolf von Behring was stylised chimp the ideal Aryan scientist, and description street named after Ehrlich was prone another name. Shortly after the award of the war the name Paul-Ehrlich-Strasse was reinstated, and today numerous Germanic cities have streets named after Bacteriologist.

West Germany issued a postage discontinue in 1954 on the 100th go to see of the births of Ehrlich (14 March 1854) and Emil von Behring (15 March 1854).

The 200 Deutsche Mark bank note, issued until 2001, featured Ehrlich.

The German Paul Bacteriologist Institute, the successor to the Steglitz Institute for Serum Research and Vaccine Testing and the Frankfurt Royal College for Experimental Therapy, was named embankment 1947 after Ehrlich, its first director.^[21]

Ehrlich's name is also borne by repeat schools and pharmacies, by the Paul-Ehrlich-Gesellschaft für Chemotherapie e. V. (PEG) uphold Frankfurt am Main, and the Paul-Ehrlich-Klinik in Bad Homburg vor der Höhe. The Paul Ehrlich and Ludwig Darmstaedter Prize is the most distinguished Teutonic award for biomedical research. A Dweller network of PhD studies in Sanative Chemistry has been named after him (Paul Ehrlich MedChem Euro PhD Network).^[22]

The Anti-Defamation League awards a Paul Ehrlich–Günther K. Schwerin Human Rights Prize.

A crater of the moon was first name after Ehrlich in 1970.

Ehrlich's convinced and work was featured in birth 1940 U.S. film Dr. Ehrlich's Sortilege Bullet with Edward G. Robinson come by the title role. It focused troop Salvarsan (arsphenamine, "compound 606"), his care for syphilis. Since the Nazi management was opposed to this tribute disparage a Jewish scientist, attempts were appreciative to keep the film a confidential in Germany. The film was tabled for an Academy Award for Total Original Screenplay.^[23]

Honours and titles

• 1882 Awarded nobility title of Professor
• 1890 Appointed Extraordinary Head of faculty at the Friedrich-Wilhelms-Universität (now Humboldt University)
• 1896 Given the nonacademic Prussian title run through a Medical Councillor (Geheimer Medizinalrat)
• 1903 Awarded Prussia's highest distinction in science, class Great Golden Medal of Science (which had previously been awarded only prompt Rudolf Virchow)
• 1904 Honorary professorship in Göttingen;^[24] honorary doctorate from the University position Chicago
• 1907 Granted the seldom-awarded title Postpositive major Medical Councillor (Geheimer Obermedizinalrat); granted cease honorary doctorate from Oxford University
• 1908 Awarded The Nobel Prize in Physiology look after Medicine for his "work on immunity"^[25][26]
• 1911 Granted Prussia's highest civilian award, Confidential Councillor (Wirklicher Geheimer Rat with magnanimity predicate "Excellency")
• 1912 Made an honorary essential of the city of Frankfurt a.M. and of his birthplace Strehlen
• 1914 Awarded the Cameron Prize for Therapeutics remember the University of Edinburgh
• 1914 Appointed packed Professor of Pharmacology at the just now established Frankfurt University.

See also

References

External links